Syd/JIP3 and JNK Signaling Are Required for Myonuclear Positioning and Muscle Function
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چکیده
منابع مشابه
Syd/JIP3 and JNK Signaling Are Required for Myonuclear Positioning and Muscle Function
Highlighting the importance of proper intracellular organization, many muscle diseases are characterized by mispositioned myonuclei. Proper positioning of myonuclei is dependent upon the microtubule motor proteins, Kinesin-1 and cytoplasmic Dynein, and there are at least two distinct mechanisms by which Kinesin and Dynein move myonuclei. The motors exert forces both directly on the nuclear surf...
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15 صفحه اولBoth internalization and AIP1 association are required for tumor necrosis factor receptor 2-mediated JNK signaling.
OBJECTIVE The proinflammtory cytokine tumor necrosis factor (TNF), primarily via TNF receptor 1 (TNFR1), induces nuclear factor-κB (NF-κB)-dependent cell survival, and c-Jun N-terminal kinase (JNK) and caspase-dependent cell death, regulating vascular endothelial cell (EC) activation and apoptosis. However, signaling by the second receptor, TNFR2, is poorly understood. The goal of this study wa...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2014
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1004880